Active-site motifs of lysosomal acid hydrolases: invariant features of clan GH-A glycosyl hydrolases deduced from hydrophobic cluster analysis
نویسندگان
چکیده
منابع مشابه
Bioprospecting metagenomes: glycosyl hydrolases for converting biomass
Throughout immeasurable time, microorganisms evolved and accumulated remarkable physiological and functional heterogeneity, and now constitute the major reserve for genetic diversity on earth. Using metagenomics, namely genetic material recovered directly from environmental samples, this biogenetic diversification can be accessed without the need to cultivate cells. Accordingly, microbial commu...
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Experiments are reported dealing with the increase of lysosomal acid hydrolases induced by BCG infection. Acid hydrolases were determined quantitatively in peritoneal MP, liver homogenate, and plasma of normal and BCG-infected mice. A significant increase of acid phosphatase, beta-glucuronidase, and cathepsin was found in MP and liver homogenate of BCG-infected mice. In plasma also a significan...
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Infection of laboratory animMs with BCG, an attenuated strain of tubercle bacilli, results in functional changes of the RES x, especially enhanced activity. The heightened phagocytic capacity may well contribute toward resistance of such animals to homologous and heterologous virulent infection (2). One of the consequences of altered activity of the RES induced by infection with BCG is the well...
متن کاملCharacterization of two new glycosyl hydrolases from the lactic acid bacterium Carnobacterium piscicola strain BA.
Three genes with homology to glycosyl hydrolases were detected on a DNA fragment cloned from a psychrophilic lactic acid bacterium isolate, Carnobacterium piscicola strain BA. A 2.2-kb region corresponding to an alpha-galactosidase gene, agaA, was followed by two genes in the same orientation, bgaB, encoding a 2-kb beta-galactosidase, and bgaC, encoding a structurally distinct 1.76-kb beta-gala...
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ژورنال
عنوان ژورنال: Glycobiology
سال: 1997
ISSN: 0959-6658,1460-2423
DOI: 10.1093/glycob/7.2.277